Search results for "methods [Protein Interaction Mapping]"

Swift follow-up of IceCube triggers, and implications for the Advanced-LIGO era

2015

Between 2011 March and 2014 August Swift responded to 20 triggers from the IceCube neutrino observatory, observing the IceCube 50% confidence error circle in X-rays, typically within 5 hours of the trigger. No confirmed counterpart has been detected. We describe the Swift follow up strategy and data analysis and present the results of the campaign. We discuss the challenges of distinguishing the X-ray counterpart to a neutrino trigger from serendipitous uncatalogued X-ray sources in the error circle, and consider the implications of our results for future strategies for multi-messenger astronomy, with particular reference to the follow up of gravitational wave triggers from the advanced-era…

Real-time Fluorescence Measurement of Enterovirus Uncoating

2019

Viruses need to open, i.e., uncoat, in order to release their genomes for efficient replication and translation. Especially for non-enveloped viruses, such as enteroviruses, the cues leading to uncoating are less well known. The status of the virus has previously been observed mainly by transmission electron microscopy using negative staining, cryo electron microscopy, X-ray crystallography or gradient separation (reviewed in Tuthill et al., 2010, Myllynen et al., 2016, Ruokolainen et al., 2019). However, monitoring of uncoating has been limited by the lack of methods detecting dynamic changes of the virions. Here, we present a real-time fluorescence based protocol, which detects the viral …

A new angle on contour integration: The role of corners

2017

Subliminal fear priming potentiates negative facial reactions to food pictures in women with anorexia nervosa.

2010

BackgroundTo investigate hedonic reactivity and the influence of unconscious emotional processes on the low sensitivity to positive reinforcement of food in anorexia nervosa (AN).MethodAN and healthy women were exposed to palatable food pictures just after a subliminal exposure to facial expressions (happy, disgust, fear and neutral faces), either while fasting or after a standardized meal (hungerversussatiety). Both implicit [facial electromyographic (EMG) activity from zygomatic and corrugator muscles, skin conductance, heart rate, and videotaped facial behavior] and explicit (self-reported pleasure and desire) measures of affective processes were recorded.ResultsIn contrast to healthy wo…

A nanodosimetric model of radiation-induced clustered DNA damage yields

2010

International audience; We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code developed to simulate the nanodosimeter. The model is based on a straightforward combinatorial approach translating ionizations, as measured or simulated in a sensitive gas volume, to lesions in a DNA segment of one-two helical turns considered equivalent to the sensitive volume of the nanodosimeter. The two model paramete…

Different preparation methods of bare and doped carbon nitride (C3N4) employed for selective photocatalytic oxidations

2018

Different preparation methods of bare and doped carbon nitride (C3N4) employed for selective photocatalytic oxidations

Lithostratigraphy of Sicily

2018

This book offers as comprehensive an overview as possible of the lithostratigraphy of the Italian region of Sicily, taking into account the multiplicity of formational and terminological variability developed over more than a century of studies and publications. It presents stratigraphic terminology, the geological lexicon and the main stratigraphic subdivisions that are not familiar to Sicilian geologists. The new stratigraphic methods and the use of formations as mapping units have prompted the acquisition of new lithostratigraphic data, and a review of the previous units and their comparison with the new collected data, enabling the definition of a number of new lithostratigraphic units.…

L'ammortamento alla francese: una questione di trasparenza

2023

Il saggio esamina i numerosi problemi posti dal c.d. metodo di ammortamento alla francese per osservare che buona parte dei problemi dibattuti sorgono dal difficile dialogo tra giuristi e matematici finanziari. Sotto il profilo giuridico rileva, in particolare, che l’ammor- tamento alla francese pone soprattutto problemi di trasparenza delle condizioni contrattuali e di comprensione, da parte del cliente, delle modalità di rimborso del capitale mutuato e dell’entità del debito residuo. The essay examines some problems posed by the so-called French amortization method to observe that most of the debated problems arise from the difficult dialogue between jurists and financial mathematicians. …

Design and analysis of discrete choice experiments for models with response time

2013

Present-day use of an empirical wave prediction method

2016

Knowledge of the offshore wave climate is key to the design of coastal engineering structures and to the study of shoreline evolution. To date, the available wave data have been limited both in time and space; even though there are several options for obtaining wave data calculated using complex numerical models at basin scale, design issues can in some cases be solved by means of simpler models. This paper shows whether, under certain conditions and in an enclosed basin, an old empirical model can provide results that are good enough to determine the design condition necessary for engineering purposes. The empirical model chosen to answer this question is called Sverdrup–Munk–Bretschneide…